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Humboldt-Universität zu Berlin - IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | News | Modeling Enzymes 100 years after Michaelis-Menten: New project from IRI Life Sciences with Princeton University

Modeling Enzymes 100 years after Michaelis-Menten: New project from IRI Life Sciences with Princeton University

IRI professor Nils Blüthgen and Prof. Stanislav Shvartsman from Princeton University successfully applied for a Joint Projects Grant within the Profile Partnership between HU and PU

Modeling Enzymes 100 years after Michaelis-Menten: A contemporary challenge with historical perspective & a blueprint for interdisciplinary research-oriented education 

Mathematical models played a key role in the development of Biochemistry, starting from Michaelis and Menten, who established a mathematical language for describing the rates of single enzymatic reactions. The project is designed to continue this great tradition, focusing on enzyme networks. We will combine biochemistry and systems biology to develop computational models of a network that is critically involved in cell-cell communication. The enzymatic reactions comprising this network are commonly deregulated in human diseases, making it an important drug target.  

In addition to carrying cutting edge research, the network will develop several educational initiatives, by organizing e.g. two international workshops, in which the participating students, postdoctoral fellows, and faculty will interact with the scientists who discovered the key molecules within the studied enzyme network.