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Humboldt-Universität zu Berlin - IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | News | Congratulations to Leonie Ringrose: new publication in Nature Communications

Congratulations to Leonie Ringrose: new publication in Nature Communications

 

"Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent" 

Kim Sneppen (University of Copenhagen) and Leonie Ringrose, Nature Communications, May 13, 2019

Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on PcG/TrxG biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.

 

Read the whole article here: https://rdcu.be/bBAdP