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Humboldt-Universität zu Berlin - IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | Events | Colloquium | Organoids | IRI-Schering Colloquium - Sina Bartfeld: Infection, inflammation and cancer in the GI tract - stem cell-derived organoids as model

IRI-Schering Colloquium - Sina Bartfeld: Infection, inflammation and cancer in the GI tract - stem cell-derived organoids as model

What
  • Organoids
When May 03, 2018 from 04:00 PM to 05:00 PM (Europe/Vienna / UTC200) iCal
Where IRI Life Sciences, Philippstr. 13, Bld. 18, 3rd Floor
Contact Name

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If you like to meet the speaker, please contact stefanie.scharf@iri-lifesciences.de

 

Abstract

The epithelial lining of the gastrointestinal tract acts as physical and immunological barrier between the microbes of the gut and the body. Chronic inflammations, for example caused by infection with the gastric pathogen Helicobacter pylori, can cause serious disease, including cancer. Gastric cancer originates from stem cells. Troy and Lgr5 are Wnt target genes specifically expressed at the bottom of gastric glands. While Lgr5 marks stem cells in the antrum, in the corpus Troy and Lgr5 together mark a subpopulation of differentiated chief cells that can regain stem cell capacity upon damage.

Mouse and human gastric stem cells can initiate ever-expanding 3 dimensional organoids in vitro. The organoids harbor stem cells, progenitor cells as well as four lineages of the stomach. Infection of organoids with Helicobacter pylori reveals cell-type specific inflammatory responses. Organoids grown from tumors as well matched healthy tissue allow evaluation of drug responses, thus indicating that organoids not only faithfully represent the healthy epithelium in vivo, but also recapitulate disease and are a useful model for the study of infection and the development of new drugs.