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Humboldt-Universität zu Berlin - IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | Events | Colloquium | Series: Microbiome | IRI Colloquium - Kiran Patil: "Uncovering metabolic and xeno-metabolic interactions in microbial communities"

IRI Colloquium - Kiran Patil: "Uncovering metabolic and xeno-metabolic interactions in microbial communities"

When Mar 02, 2017 from 04:00 PM to 05:00 PM (Europe/Vienna / UTC100) iCal
Where IRI Life Sciences, Philippstr. 13, Bld. 18, 3rd Floor
Contact Name

Microbial communities populate most environments on earth and play a critical role in ecology and human health. Their composition is thought to be largely shaped by interspecies competition for the available resources, but cooperative interactions, such as metabolite exchanges, have also been implicated in community assembly. The prevalence of metabolic interactions in microbial communities, however, has remained largely unknown. I will present a genome-scale metabolic modeling approach, termed SMETANA, which allows gauging the extent of resource competition and metabolic exchanges complex communities. Our results highlight metabolic dependencies as a major driver of species co-occurrence and hint at cooperative groups as recurring modules of microbial community architecture. I will also present our latest experimental work on discovering metabolic and xeno-metabolic interactions in gut microbial and other communities.