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Humboldt-Universität zu Berlin - IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | Events | Colloquium | Series: Life in Numbers | IRI-Schering-Colloquium - Peter Lénárt: "The same, only different: how does the cytoskeleton adapt to meiosis-specific functions?"

IRI-Schering-Colloquium - Peter Lénárt: "The same, only different: how does the cytoskeleton adapt to meiosis-specific functions?"

When Jun 01, 2017 from 04:00 PM to 04:30 PM (Europe/Vienna / UTC200) iCal
Where IRI Life Sciences, Philippstr. 13, Bld. 18, 3rd Floor
Contact Name

 

coll.png​   Schering

 

 

Peter Lénárt is Group Leader at the EMBL Heidelberg of the group "Cytoskeletal dynamics and function in oocytes".

Using starfish as a model organism, the Lénárt group combines biochemistry with imaging assays to investigate how the fertilisable egg cell develops from the oocyte.

 

Abstract:

We are generally interested in how the cell division machinery, the cytoskeleton in particular, adapted to divide the large oocyte in a highly asymmetric manner to produce a single fertilizable egg, filled with nutrients to support embryonic development. I will present two examples for such meiosis-specific adaptations. First, as chromosomes scattered in the exceptionally large oocyte nucleus are located too far from the spindle to be efficiently captured by microtubules, an additional, actin-dependent mechanism is required to transport chromosomes to within their capture range. In recent work, we revealed that this F-actin network transporting chromosomes contracts by a novel, depolymerization-driven mechanism. Second, I will show how the cytokinetic machinery adapted to support divisions in large oocytes manifesting as coordinated waves of cortical contractions traveling across the cell.

 

If you like to meet our speaker for a personal discission, please contact stefanie.scharf@iri-lifesciences.de