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Humboldt-Universität zu Berlin | IRI Life Sciences | Events | IRI Talks | Dates | IRI Talk - Philipp Rauch: "Accessing Forces in Biology from Single Molecules to Cells. Introducing the AFS and C-Trap technology"

IRI Talk - Philipp Rauch: "Accessing Forces in Biology from Single Molecules to Cells. Introducing the AFS and C-Trap technology"

What
  • IRI Talk
When Nov 08, 2017 from 02:00 PM to 03:00 PM (Europe/Vienna / UTC100) iCal
Where IRI Life Sciences, Philippstr. 13, Bld. 18, Maud Menten Hall, 3rd Floor
Contact Name

Invitation lila

Philipp Rauch

LUMICKS B.V. Amsterdam

Accessing Forces in Biology from Single Molecules to Cells

Introducing the AFS and C-Trap technology

 

Abstract:

In the last years, the role and importance of forces in biological and biochemical processes has moved more and more in the focus of research disciplines ranging from physical (bio-)chemistry to molecular and cell biology. This is of course not limited to macroscopic forces but scales down to the dynamics of individual molecules and their interactions. The activity of motor proteins, enzymes and mechanical processes of cell division (e.g. chromatid segregation) are only few examples where the generation and control of forces on a nanoscale level is crucial for the reliability of the process.
At LUMICKS we dedicate our technical knowledge and expertise in molecular and cellular biology and biophysics to the development of advanced instrumentation for applying and measuring the smallest forces in biological samples. The core technologies we develop are acoustic force spectroscopy (AFS) and correlative optical tweezers – confocal fluorescence. While the latter combines two established methods of single molecule research at the highest level to gain new insights into dynamic molecular processes and structure, AFS is a new technology that uses ultrasound to apply well-defined forces to single molecules, filaments or cells in a highly parallelized design.
Applications that will be introduced include single molecule force spectroscopy (e.g. protein unfolding, mechanics of DNA or cytoskeletal filaments), molecular dynamics, binding studies, membrane dynamics and fusion and cell adhesion / immunology.