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IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | Events | IRI Talks | Dates | IRI Talk - Ivo Telley: "Drosophila early embryogenesis under a new light "

IRI Talk - Ivo Telley: "Drosophila early embryogenesis under a new light "

What
  • IRI Talk
When Feb 25, 2016 from 05:00 PM to 06:00 PM (Europe/Vienna / UTC100) iCal
Where Philippstr. 13 Haus 18

Ivo Telley

Instituto Gulbenkian de Ciência, Lisbon

 

Insect embryogenesis begins with fertilization of the egg inside the female animal, triggered by sperm entry and pronuclear apposition. After several rounds of nuclear multiplication the egg turns into a blastoderm in only 90 minutes. To date, the migration and fusion of the male and female pronuclei, and the first nine mitotic divisions are largely understudied and existing evidence provides a fragmented and descriptive picture of events. This is due to the size of the egg, filled with diffractive particles, which challenge every state-of-art live microscopy technique. Because of this limitation we lack any dynamic (temporal) information on the molecular and morphological level. My team has adopted an ex vivo approach to study nuclear and cytoskeletal dynamics in explants of the early (0–90 min) Drosophila melanogaster fertilized egg and embryo. I will talk about our recent progress in quantifying nuclear distribution and separation, in characterizing microtubule-associated proteins that are involved in this process, as well as our first attempts in time-lapse visualizing pronuclear apposition and the first mitotic division just after fertilization.