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Humboldt-Universität zu Berlin | IRI Life Sciences | Scientific Events | Colloquium | Heterogeneity | CANCELLED! IRI-Colloquium Heterogeneity in Biological Systems: Roi Avraham - “Predicting human infection outcome using single cell RNA-seq of blood immune cells”

CANCELLED! IRI-Colloquium Heterogeneity in Biological Systems: Roi Avraham - “Predicting human infection outcome using single cell RNA-seq of blood immune cells”

When Mar 05, 2020 from 04:00 PM to 05:00 PM (Europe/Vienna / UTC100) iCal
Where IRI Life Sciences, Philippstr. 13, Building 18, 3rd Floor, Room 410
Contact Name
Contact Phone 030209347904

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Speaker: Roi Avraham, Weizmann Institute of Science

Title: Predicting human infection outcome using single cell RNA-seq of blood immune cells

 

Abstract:

Management of many bacterial infections is becoming increasingly difficult due to new and rapidly evolving pathogens with increased virulence and drug resistance. Promising alternative approaches to targeting pathogens are to harness the host’s own response to infection or to target virulent processes of the pathogen. To realize these intriguing alternatives, a comprehensive and systematic understanding of the complex dynamics between host and pathogen is required. Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?

In this talk, I will demonstrate our approach that applies single cell analysis of models of infection of cultured blood immune cells with different pathogens and of human patient samples. We elucidate the complexity of the human immune system in health and disease, to understand what are the important determinant for successful control of infection. This approach allowed us to identify cell-type specific activation biomarkers that can predict risk to infectious diseases, and also provide indications to changes in immune correlates at very easy stages of infection.