Direkt zum InhaltDirekt zur SucheDirekt zur Navigation
▼ Zielgruppen ▼

IRI Life Sciences

Humboldt-Universität zu Berlin | IRI Life Sciences | Scientific Events | Colloquium | Heterogeneity | IRI-Colloquium Heterogeneity in Biological Systems: Steven Altschuler - Cellular decisions in rapidly dividing tissues

IRI-Colloquium Heterogeneity in Biological Systems: Steven Altschuler - Cellular decisions in rapidly dividing tissues

When Feb 06, 2020 from 04:00 PM to 05:00 PM (Europe/Vienna / UTC100) iCal
Where IRI Life Sciences, Philippstr. 13, Building 18, 3rd Floor, Room 410
Contact Name
Contact Phone 030209347904

Header

 

Speaker: Steven Altschuler, University of California

Title: Cellular decisions in rapidly dividing tissues

 

Abstract:

We will talk about recent progress in understanding how cells make decisions in rapidly dividing populations. In the first part, we will report on single-cell cancer fate decisions after non-lethal dose of chemotherapy. Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. In the second part, we will report on how network crosstalk in the intestinal epithelium regulates cell lineage decisions. We will make use of a novel 2-D gut organoid culture system to dissect how small intestinal epithelium translates combinatorial signals into changes in cell-type composition. Our study helps links the size of the proliferating progenitor compartment with cell-fate specification, enabling a unified and diverse response to the microenvironment.